It is unlikely that it will happen but think about it : the MCU has the tendency to combine different elements of the comics into one single concept.
For example, the Cosmic Cube & the Space Infinity Gem or the Eye of Agamotto & the Time Infinity Gem.
Could it be possible that the Ten Rings and the Hand are two aspects of the same secret society ?
If that's true ... does it mean that Sigourney Weaver would be revealed as the true MCU "Mandarin" ?
What if her character is a tai-pan ?
It is unlikely (the Netflix sub-verse is autonomous) but it would be a clever way to resolve the mystery of the Ten Rings leader.
Also, if there is a woman who can defeat Iron Man, that's Sigourney Weaver !
NB : I realize that her Alexandra Reid character doesn't currently behave like the Mandarin of the comic books ...