The same way that The Kingpin, Bullseye, Joker, Ra's Al Ghul, Green Gobin or Doctor Octopus have done. Heck, it seems that The Ghost has left a bigger impact and cemented himself as more of an Iron Man villain that The Mandarin ever has. That's why I think that Hammer ad Stane are really Tony's arch-villains.
Stan Lee gave the Mandarin an origin that combined the pathos of The Penguin and Roman Sionis, aristocrats whose parents hated them, with the pathos of X-23, a child raised to be a super-soldier/living weapon. And then topped it off with the topical darkness of Christopher Columbus style exploration, colonialism, imperialism, and exploitation. It's a great origin whose only flaw is only being five pages long.
And then...subsequent writers did absolutely nothing with any of that. Instead they gradually boosted the rings up and up and up, which is absolutely the most boring thing you could possibly do with that character. It's a deterioration on a par with the Batman & Robin version of Bane, a mindless nothing completely dependent on venom to do anything.
Personally I think they need to mostly ignore everything past the Bronze Age, go back to Stan Lee's origin, and mine it and expand it to flesh out the character. Everything past the Bronze Age has not only not fleshed him out, it's thinned him down.