I remember when "relevance" was a big thing for Marvel back in the 60s and 70s. I used to think it was pretty cool. But I was ten.
Nowadays I don't want to see a single panel depicting or even discussing these topics:
2. Spousal abuse
3. Child abuse
4. Drug addiction
Two "relevant" topics I would be OK with are:
2. Mass shootings
But the bully must receive stern (even savage) justice from his victims and the mass shooter must encounter the likes of Captain America who must save the day, utterly thwarting the shooter.
Generally, I don't want to read about helpless (and hopeless) victims in comic books. I know they abound in real life. But I don't want real life to encroach too far into my comics. Helpless victims in comics simply aren't fun unless a superhero eventually smashes through the window from outside and pounds the perp into pulp before the victim is harmed. The hope of rescue must always be there.
If we absolutely must have thugs who threaten rape, then let the intended victim be an undercover superhero who smashes the rapist into the dirt.
I don't want my supervillains to be rapists. Rape is a cowardly act. I don't want my supervillains to be cowards. They defy the system, law enforcement and the superhero community. There has to be bravery in that despicable breast. That bravery is one of the elements that makes the supervillain fun.
If that's what you mean by "relevant," then I want them relevant 9 days a week... and twice on Sunday. Otherwise, why bother.
Stories can still be "relevant" and fun and exciting.
I don't think we had any sort of "relevancy" in the 60s. It's more a product of the Bronze Age, beginning in the 70s.