The whole thing makes no sense. The only thing that changed was the wedding was aborted, hence no future kid.
Now MJ falls back on the old trope that she can't handle the idea of losing Peter to a supervillain but also won't stop him from being Spider-man as she knows Peter can't stop and she wouldn't handle the guilt of making him stop.
Anyone get the impression that Mephisto has planted a few commands in her mind?
EVERYTHING ELSE happened the way it happened. They did live together, almost had a kid until Clone Saga 2 and Osborn being retro'd back to life to fix that junkpile ended the kid. Aunt May still dies in ASM 400 only to be retconned back to life. She still learns Peter is Spidey, he still unmasks in Civil Bore and Aunt May still gets shot.
Except that they were not married.
This is all Joe Q's doing because he felt the marriage and a divorce would make Peter unrelatable to readers....but dealing with the Devil is okay....
But as Joe Q has stated: "SHUT UP! IT'S MAGIC! WE DON'T HAVE TO EXPLAIN IT!"
They need to do in the main book what was done in Renew Your Vows: Give MJ super powers. While Spider powers would be obvious they don't have to be spider-powers. have her merge with a benign symbiote from Venom's world, or have the venom symbiote temporarily bond to her, then leave her and we can make her the next Anti-Venom.
Give her a Rescue style of Iron Man armor like Pepper had.
Give her a blood transfusion from Jim Android Torch Hammond and let her gain some flame powers from it and make her the new Firestar.
Or have Dracula put the bite on her but due to interference or magic from Dr Strange she isn't cured but is now a daywalker like Blade.