Which villain, given his powers (or lack thereof), has been the most ridiculously successful against Spider-Man? A couple I can think of are the Jackal back in the '70s, who won every battle he had with Spidey despite having no superhuman powers and being a probably fortysomething college professor, and Hammerhead, whose metallic skull apparently protects his entire body from injury (to the point that his being at ground zero of a nuclear reactor exploding turns him into ethereal form rather than kills him).