I'm never a TPB type of person. Given the choice, I'll always opt for issue by issue. I enjoy the pamphlet size, cliffhangers, and waiting between parts.
You come out better spending $50 for the 16 issues with the HC, but you also have to wait until July, whereas the story will be done by May. If you don't mind waiting, and prefer HC/TPBs, then go that way.
I don't think it matters as much since this story is weekly.
Well heck, I hit the LCS today and they are already sold out.. look around and they are sold out everywhere. Then my comic collector habit kicked in and I'm paying 3 times more than cover price on ebay after adding 'em to my pull list. But at least I did score the Davis cover for 676. Worse than a smoking habit if you ignore the lung cancer.