In Earth X the Watcher was blind because his eyes had been removed, Thor was a woman, Silver Surfer flew with a woman on his board, Old Man Steve Rogers existed, Fury LMDs are all that existed, Hydra squids were on everyone's heads and President Osborn was in charge. Has Marvel been heading in this direction since Original Sin? Admittedly Osborn only ascended to Director of HAMMER but still look at what’s coming up with Secret Empire!
Borrowing themes is common. Still with the celestials dead and many other universes characters folded in, i doubt it.