Previous Post No not really, He's already matched up against some of those you listed but not made an impression. It does tends to hinge on circumstance and whether the Brick is ready/expecting the hit. All his beams are is a concussive force, most often they actually deflect off an invulnerable opponent if the angle is not dead centre. A more ruthless and focused use of the beams potency however saw him effortlessly drill a small hole right thru The Blobs shoulder in X-Factor so some of this comes down to how he chooses to use the beam.

albeit he hit him from behind and Colossus was mind-controlled (during the Asgardian arc).