Wonder Man had a body armour of Amazing (50) which absorbed that amount of damage. He had Monstrous (75) Endurance which is his ability to handle attacks which hurt him and he now has a Health of 225, which when reduced to 0, calls on his Endurance to prevent from dying.
Thor, on the other hand has natural body armour of Excellent (20). His Endurance is Unearthly (100) and he now has health of 340.
So going by these statistics, Wonder Man could safely ignore punches from Luke Cage, Loki and classic Rogue with no ill effect, whilst Thor could completely ignore punches from Captain America and the Kingpin. In theory, Kraven, Tigra or The Beast could beat Thor to death if they hand long enough and Thor didn't defend himself.
Thing with his Monstrous (75) damage would hurt Thor more - hitting each time for 55 points of damage, but doing 25 points of damage to Wonder Man, so Thor's greater health would diminish more quickly. Although his Endurance would allow him better success against getting ko'd or dying (but he would be doing more rolls than Wonder Man).
An enraged Hulk on the other hand, with say Shift X damage (150), would badly hurt either Wonder Man (100 points of his 225 pool) or 130 points to Thor's 340 pool. Whilst both would be overwhealmed by 3 punches (based on game mechanics and ignoring evading (which Thor would be better at or Karma -which Thor has more of). Thor's Endurance would allow to stay on his feet longer. It should also be noted that Thor's armour provides Incredible (40) armour, making the advantage Simon has more negligible).
While fun, some of these do not seem to reflect the comics too much. Thor has taken some beatings from Hulk and still gotten up, although looking dinged up.
That said, it is a fun enough game for what it is trying to do. And one of the most complete in terms of scope.