OK friends you're given the power to amend the US constitution.
Can be as detailed or a simple as you want
it can simultaneously repeal a related clause
However the main restriction is that it is only allowed to deal with one subject. For example if your amendment deals with gun rights, you can't also make a clause for a term limits. If you have a balanced budget amendment you can't simultaneously eliminate the electoral college.
I would abolish either the FED or The FDA. The FED itself is really unless, and from my research, definitely unconstitutional. The FDA is on better grounds constitutionally, but they're corrupt as all-get-out and considering how many addictive and dangerous drugs that they APPROVE are out on the market, they're pretty much useless.