RE: Doctor Who.
ISTR Reed did this before (Four Freedoms Plaza?) waaaaaaaaaaaaaaaay back, and, when asked about it, had a friend who was a "Doctor".
It's not the first reference, as Byrne used to reference the show a fair bit, and, of course, Steve Englehart had the word "TARDIS!" as a sound effect:
I've got most of the Byrne issues, but I don't really remember much Dr. Who references. The only one I remember is Dame Ruth Efford dressed similar to Tom Baker's Doctor in issue #239. I wouldn't mind seeing her again.