I wonder if this touches back all the way to the beginning.
After all, Brian was the first outside force to enter his system. Who was "riding" Sasquatch at the time. Who, I might add, still hasn't returned from the dead since #21. And the solicit for #40 mentions a new Sasquatch guarding the door.
Similarly, the iron hotel brings to mind to iron maiden like prison that Devil Hulk is currently imprisoned in his mind.
I wonder if Tanaraq might be there in the mix as well.
The thing I'm most interested in, is that Joe has once again got free reign over the host body. Last time it happened in #18, he had exerted control for a while and got into all sorts of trouble.
Btw, where's the cover for #41? I can't seem to find it.