Honestly Invincible is worth reading from issue 1 on up, but thats not always realistic. A fellow poster on these here boards actually hooked me years ago by giving me the first 2 trades and now the CyberCoyote Bookshelves are sagging under the weight of the mighty load.
Recently a free issue was released (118) and if you arent adverse to digital #1 is free also. As far as the best recent jumping on point... the mentioned 118 was touted as such but personally I'd point to 105 which was a point where the Real Invincible came back to the series officially after some time away with a fill in friend. It also begins the amazing story that leads to Mark and his family now living off world. And you'll unfortunately get the WHOLE picture of why Hester's book couldn't continue.
First rule of Invincible; Don't let yourself get too attached to characters in Invincible (as if the great writing allows you to do that)
I'll see what I can do at finding back issues or trades from 105 up. Eventually, maybe, I'll start filling in the first 100 issues with TPB and such. I'm at least starting to get an idea of what kind of Christmas list to give to my family this year!
I look back at what I've been reading out of loyalty and habit the last decade and wish I really had got out of my comfort zone. So much great indie work out there I've overlooked, but, it will be fun to go on the hunt again and find some of these treasures. Thanks Cyber!