His street-level work was good (Daredevil, Luke Cage, Jessica Jones, Iron Fist, Miles Morales) but as soon as they gave him the keys to the 616 Universe, things went bad. And the list of characters he burned to the ground or completely sold out and the continuity he completely dumped on or just flat out ignored is unforgivable. His good work pales in comparison to the damage he has done.
Here are just a few of the character he "jobbed", never liked, never understood or flat out destroyed: (this is just a few, feel free to add more)
Nova (Richard Rider)
Beast (as an Avenger & Xmen)
Wolverine (as an Avenger)
The Fantastic Four
The whole of the X-Men Universe
The whole of the Guardians of the Galaxy
The concept of the Thunderbolts
I did a big post on this here before, but very few characters in ongoing fiction can be destroyed or ruined forever. Those sound like changes or stories that you didn't like. Also, what did he do to or with the Thunderbolts? To my knowledge, he never even touched the book.