I was thinking about all of the deaths that have impacted Peter, and everyone just seems to mention the big three: Uncle Ben (Of course.), Gwen Stacy, and Captain Stacy (Although he's not mentioned that much.). When Harry Osborn was dead, it used to be Uncle Ben, Gwen, Cap, and Harry Osborn, but he's back, so that takes him off the list. And when Norman Osborn was dead, his death impacted Peter as well. And I guess Miles Warren, as they were somewhat friendly.
But a LOT of people close to Peter have died, the three above being big examples of deaths that SHOULD be brought up a lot, as they were all his friends and allies. Jean De Wolff in particular was an ally and a friend. Ben Reilly goes without saying, but the Clone Saga drove away so many fans, and caused so much financial trouble for Marvel, that I can see why his death is never mentioned or brought up. But what about Ned Leeds? When Jason Macendale was the Hobgoblin, other than his first appearance, Peter never seemed to bring up the fact that he was somewhat responsible for the death of Ned. Whenever Peter and Norman meet, Gwen's death is almost ALWAYS mentioned, but the death of Ned didn't seem to bring any real animosity to the relationship and hatred between Peter and Jason. So yeah, three people close to Peter, but for some reason, their deaths never get brought up. Which is kind of puzzling. Peter has had a lot of tragedy in his life, that was a running theme during the Mark Millar run on Spider-Man (Which, as poor as I thought that it was, handled that part well.). In fact, I think that TOO many people close to him have died, and have been hurt. But I find it puzziling that we never hear any mention of these three. I don't want them to be brought up as much as Uncle Ben or Gwen, but I think that they definitely do deserve a mention, especially Jean and Ben. Ned Leeds, I guess that they weren't too close. Another death that I think should be brought up would be Nathan Lubensky, who was Aunt May's old flame.